Close Menu
  • Home
  • News
  • Lifestyle
  • Law
  • Business
  • Education

Subscribe to Updates

Get the latest creative news from FooBar about art, design and business.

What's Hot

Pennsylvania House Passes Cannabis Legalization Bill

May 8, 2025

Cannabis Company CEO Considering New Mexico Gubernatorial Bid

May 8, 2025

U.S. Supreme Court Declines to Hear Challenge to Medical Cannabis Advertising Ban

May 8, 2025
Facebook X (Twitter) Instagram
Friday, May 9
  • Home
  • Contact
  • Privacy Policy
  • Terms & Conditions
Facebook X (Twitter) Instagram LinkedIn VKontakte
Smoke Professional
  • Home
  • News

    More Than 1,000 Arrested in Sweep of U.K. Weed Grows

    July 8, 2023

    Scotland Calls On UK To End ‘Failed’ Drug War With Decriminalization And Harm Reduction Approach

    July 8, 2023

    Germany’s draft law for first phase of cannabis reform

    July 8, 2023

    High Times Cannabis Cup Illinois: People’s Choice Edition 2023 Kicks Off

    July 8, 2023

    Pennsylvania Committee Advances Expansion to State Medical Cannabis Program

    July 7, 2023
  • Lifestyle

    How Watching the News Can Trigger Anxiety and Panic Attacks

    October 28, 2024

    Record High Cannabis and Hallucinogen Use Among Adults

    October 27, 2024

    Weekend Sleep Catch-Up May Lower Heart Disease Risk by 20%

    October 27, 2024

    Energy Drinks Linked to Poor Sleep Quality and Insomnia

    October 26, 2024

    First Psychedelic Church for Magic Mushrooms

    October 26, 2024
  • Law

    Pennsylvania House Passes Cannabis Legalization Bill

    May 8, 2025

    Nebraska Lawmakers to Reconsider Bill to Implement Voter-Approved Medical Cannabis Law

    May 7, 2025

    Bill to Legalize Adult-Use Cannabis Filed in Pennsylvania

    May 6, 2025

    New Hampshire Senate Blocks Adult-Use Cannabis Legalization Bill

    May 2, 2025

    Cannabis Taxation: C Corp, S Corp, LLC, LLP, Partnership, Nonprofit, or Something Else for Your Cannabis Business?

    April 30, 2025
  • Business

    Cannabis Company CEO Considering New Mexico Gubernatorial Bid

    May 8, 2025

    U.S. Supreme Court Declines to Hear Challenge to Medical Cannabis Advertising Ban

    May 8, 2025

    Minnesota Cannabis Licensing Lotteries Scheduled for June 5

    May 7, 2025

    Ohio Senate Passes Bill Imposing New Regulations on Intoxicating Hemp Products  

    May 6, 2025

    Tax Hikes Coming to California Cannabis Industry

    May 5, 2025
  • Education

    CBD and the Aging Population—What Science Says Today

    March 12, 2025

    Wholesale Nootropic Skincare: Boost Your Product Line

    March 10, 2025

    Ideal for Your Business Needs

    March 8, 2025

    A Must-have For Every Smoke Shop

    March 3, 2025

    The Perfect Addition to Your Product Line

    March 1, 2025
Smoke Professional
You are at:Home»Education»Psychedelic Toad Toxins Could Treat Depression, Anxiety Without Hallucinations
Education

Psychedelic Toad Toxins Could Treat Depression, Anxiety Without Hallucinations

adminBy adminMay 16, 2024No Comments4 Mins Read
Facebook Twitter Pinterest LinkedIn Tumblr Email
Share
Facebook Twitter LinkedIn Pinterest Email

Hallucinogenic compounds that activate multiple receptors, found in Colorado River toads, show “promising transdiagnostic therapeutic with rapid and lasting effects” for conditions such as depression and anxiety, new findings show, and you don’t necessarily need to hallucinate to therapeutically benefit from the compounds. 

While much is known about the serotonin 5-HT2A receptor, this study explored a serotonin receptor called 5-HT1A, which is activated by an altered compound made from toad secretions that’s believed to alleviate depression and anxiety without inducing hallucinations.

A new study, “Structural pharmacology and therapeutic potential of 5-methoxytryptamines,” was published last month in the journal Nature.

When sensing danger, Colorado River toads, sometimes native to the Sonoran Desert (Incilius alvarius or Bufo alvarius) release a hallucinogenic compound bufotenin that’s structurally similar to DMT from glands in their skin. The compound is also similar in structure and effects to psilocybin as well. The marine toad (Bufo marinus) and European green toad (Bufo viridis) release similar toxins that can sometimes be poisonous to the touch, but only the Colorado River toad releases compounds considered a true hallucinogen.

A team of researchers from Mount Sinai Hospital and Columbia University in New York explored the potential health benefits of psychedelic compounds from toad secretions, and created a new compound that doesn’t trigger hallucinations. 

“We became intrigued by numerous reports of powerful, unique and life-changing experiences associated with its ritualistic or experimental clinical use, which made us wonder about its therapeutic potential and the underlying mechanisms,” David Lankri, a neuropharmacologist at Columbia University and a co-author of the study, told Gizmodo.

Since it’s structurally similar to psilocybin, and based on evidence showing that psilocybin can treat depression in some people, researchers believe there is therapeutic potential with toad secretions as well. 

Most psychedelics research has explored the drug’s effects on a particular kind of serotonin receptor called 5-HT2A. But the team behind the new study focused on a more obscure serotonin receptor called 5-HT1A, which past studies suggest interacts with the toad toxin.

A New Compound Made from Toads

Smithsonian reports that by slightly modifying the 5-MeO-DMT compound, the researchers created another compound called 4-F,5-MeO-PyrT. This new compound interacts primarily with 5-HT1A, a pathway that appears to offer the same antidepressant and anti-anxiety effects without inducing hallucinogenic trips.

It turns out there are already pharmaceutical drugs that target the same receptor.

“Given that 5-HT is the primary target of approved anxiolytic and antidepressant medications, such as buspirone (BuSpar)  and vilazodone (Viibryd), this receptor may contribute to the reported therapeutic effects of 5-MeO-DMT.”

The effects from psychedelic toad secretion compounds suggest long-term effects in overcoming depression-like states.

“Recent preliminary clinical data suggest that 5-MeO-DMT is a promising transdiagnostic therapeutic with rapid and lasting effects. Our work and previous studies have shown that 5-MeO-DMT has comparable signaling potency and efficacy at 5-HT and 5-HT in vitro, and both receptors contribute to its in vivo pharmacology. In light of previous work showcasing 5-HT-selective agonists that alleviate anxiety-like and depression-like states in preclinical models, we wanted to investigate the role of 5-HT in both psychedelic and therapeutic effects of 5-MeO-tryptamines. Although 5-HT is a validated therapeutic target for several approved medications, including vilazodone and buspirone, the importance of 5-HT agonism to the therapeutic effects of tryptamine psychedelics has not been conclusively addressed.”

High Times reported on the toad using its other name, the Sonoran Desert toad, with glands secreting a venom rich in the hallucinogens 5-MeO-DMT and bufotenin, which invaded Arizona last year when monsoon conditions kicked in for the late summer. They can measure up to 7 inches long and have a low-pitched croak that inevitably serenades the night in multiple states during hot wetter months.

Local news stations in Arizona last year reported a surge in Sonoran Desert toad populations now that the rain has started. 

While some researchers aim to bypass the hallucinogenic effects of the toxin, others are trying to enhance it for recreational use. They are sought after so much, toad secretion harvesting has caused them to be endangered in some areas.

Vice Media’s Hamilton Morris documented the Sonoran Desert toad in detail—calling the toads’ secretion the “most potent psychedelic toad venom on Earth,” which also makes it ideal for medical research. Sonoran Desert toad venom should only be vaped or smoked, InStyle reported. Toad venom is scraped from the glands on the animals and dried into a paste, which is later smoked. “The experience is going to start within 10 to 30 seconds and then you’re going to be physically incapacitated for 20 to 30 minutes,” Alan Davis, a Johns Hopkins psychedelics researcher, previously explained in Johns Hopkins Magazine. 

Source link

anxiety Depression Hallucinations Psychedelic Toad Toxins treat
Share. Facebook Twitter Pinterest LinkedIn Tumblr Email
Previous ArticlePsilocybin Doesn’t Alter Belief or Disbelief in God, Study Suggests
Next Article Willie and Annie Nelson Announce Cannabis Cookbook
admin
  • Website

Related Posts

CBD and the Aging Population—What Science Says Today

March 12, 2025

Wholesale Nootropic Skincare: Boost Your Product Line

March 10, 2025

Ideal for Your Business Needs

March 8, 2025

Comments are closed.

Our Picks

Pennsylvania House Passes Cannabis Legalization Bill

May 8, 2025

Cannabis Company CEO Considering New Mexico Gubernatorial Bid

May 8, 2025

U.S. Supreme Court Declines to Hear Challenge to Medical Cannabis Advertising Ban

May 8, 2025

Minnesota Cannabis Licensing Lotteries Scheduled for June 5

May 7, 2025
  • Facebook
  • Twitter
  • Pinterest
  • Instagram
  • YouTube
  • Vimeo
Don't Miss
Law

Pennsylvania House Passes Cannabis Legalization Bill

By adminMay 8, 20250

The Pennsylvania House of Representatives on Tuesday gave initial approval to an adult-use cannabis legalization…

Cannabis Company CEO Considering New Mexico Gubernatorial Bid

May 8, 2025

U.S. Supreme Court Declines to Hear Challenge to Medical Cannabis Advertising Ban

May 8, 2025

Minnesota Cannabis Licensing Lotteries Scheduled for June 5

May 7, 2025

Subscribe to Updates

Get the latest creative news from Smoke Unlimited about Weed & CBD vaping.

From Our Partners
About Us
About Us

Get all the current news stories, latest trends and legislation regarding cannabidiol, products, usages and its benefits. So don’t miss out any buzz and stay tuned! We offer a minute to minute updates regarding Marijuana industry.

Facebook X (Twitter) Instagram Pinterest
Our Picks

Pennsylvania House Passes Cannabis Legalization Bill

May 8, 2025

Cannabis Company CEO Considering New Mexico Gubernatorial Bid

May 8, 2025

U.S. Supreme Court Declines to Hear Challenge to Medical Cannabis Advertising Ban

May 8, 2025
Sponsors
Copyright © 2025. SmokeProfessional
  • Home
  • Contact
  • Privacy Policy
  • Terms & Conditions

Type above and press Enter to search. Press Esc to cancel.