The information shared in this post is for informational purposes only and should not be considered as a replacement for professional medical advice. The statements made on this article regarding CBD have not been evaluated by the Food and Drug Administration. The efficacy of CBD has not been confirmed by FDA-approved research. CBD is not intended to diagnose, treat, cure or prevent any disease. Consult your doctor before using CBD, especially if you have any medical conditions. Your doctor can help determine if CBD is right for you.
If you experience allergy symptoms and want to explore CBD’s potential impact, this article may provide valuable insights.
The way CBD interacts with the immune system is suggested to play a large role in CBD’s potential to alleviate annoying allergy symptoms.
Some individuals have reported finding potential for improved allergy symptoms with CBD products, especially since they don’t contain the intense sedative-like effects common in over-the-counter medications and other allergy meds.
Here we’ll take a deep dive into the potential of using CBD for allergies, its potential to reduce inflammation, how it compares to traditional allergy treatments, and more.
What You’ll Takeaway
- The way CBD may support inflammation and the immune response connected to allergies is the way the compound works with the endocannabinoid system.
- There is some indication that CBD may have properties that could contribute to a reduction in allergy symptoms, including inflammation-related symptoms such as vasodilation and cytokine release.
- While initial research suggests a potential role for CBD as a natural option for managing allergies, further studies are needed to fully understand its effects as a natural antihistamine.
Understanding the Connection Between Allergies and the Immune System
Research suggests a significant connection between allergies and the immune system. Allergies are immune system responses to otherwise harmless substances, otherwise known as allergens. (1)
Allergies affect people of all ages, but they’re typically most common in children. It’s important to know that allergies that have been in remission for years can suddenly return.
Common allergens include dust, pollen, mold, and pet dander. When you come in contact with these allergens, the immune system can overreact. This leads to an overproduction of antibodies, which triggers the release of histamine and other chemicals. Ultimately, this is what causes allergy symptoms like runny nose, nasal pressure, itchy skin, watery eyes, and wheezing. (1)
Hay fever (aka allergic rhinitis) and asthma are common allergic conditions. Many people also suffer from various food allergies. In serious cases, allergic reactions can include anaphylaxis, a life-threatening reaction that causes tissue swelling and a sudden drop in blood pressure. (1)
Seeing how widespread allergies are, as well as the myriad of allergy symptoms, discovering ways to effectively manage allergies is key.
CBD has garnered attention for its potential as an alternative option for managing allergies, though additional research is required to validate its efficacy compared to traditional allergy medications. (2)
The Science Behind CBD and Allergic Responses
The relationship between CBD and allergic reactions centers on its influence on the endocannabinoid system (ECS). Shown to play a large role in regulating immune system responses, the ECS is directly connected to how the body reacts to different allergens. (3, 4, 5)
There is a particularly large concentration of CB2 receptors located in the immune system. Some theories suggest that CBD’s interaction with the ECS may modulate immune responses associated with allergies, potentially affecting inflammation levels. (6, 7, 8)
CBD’s possible impact on inflammation may have implications for managing allergy-related symptoms, though more research is necessary to confirm its effectiveness. While research is still in its early stages, preclinical trials are promising. (7)
Preliminary evidence suggests that cannabinoids, including CBD, may have anti-inflammatory effects on airway inflammation and could potentially support immune system function, though further investigation is needed. (9)
The Potential Anti-Inflammatory Effects of CBD on Allergy Symptoms
CBD’s suggested anti-inflammatory properties show some serious promise to relieve allergy symptoms. How exactly does it work?
During an allergic reaction, CBD works in a few different ways.
- CBD may reduce blood vessel dilation, which is caused by the release of histamines and can lead to dangerous drops in blood pressure.
- CBD might decrease the number of immune cells that migrate to the inflamed area through the direct suppression or activation of various immune cells.
- CBD could possibly release pro-inflammatory cytokines through its influence on cannabinoid receptors.
All of these can help reduce allergic inflammation and allergy-related symptoms. (7)
In conditions like hay fever, CBD’s immunosuppressive and anti-inflammatory properties may control inflammation. This could help relieve common symptoms of hay fever, such as itchy nose, sneezing, watery eyes, and more. (8)
What Types of CBD Products Can Be Used for Allergies?
Several different CBD products are commonly used to support allergies. Depending on how you want to manage allergy symptoms, CBD topicals, sublingual, and inhalable products are all used to support the allergic response.
When choosing the best products for your personal needs, keep things like sourcing, extraction methods, product quality, and strength in mind.
Always insist on CBD products that have been third-party lab tested to ensure quality and safety standards.
Is Full-Spectrum, Broad-Spectrum, or CBD Isolate Best for Allergies?
Are you curious if full-spectrum or broad-spectrum CBD is better for allergy support than CBD isolate? Do these different types of CBD products make a difference in relieving allergy symptoms?
It’s a matter of personal preference, and knowing what makes them different can help in your decision.
Full-spectrum CBD contains CBD, less than 0.3% THC, other minor cannabinoids, terpenes, flavonoids, and other compounds that work together to create the entourage effect. This could enhance the effects of full-spectrum CBD products on allergies. (11)
Broad-spectrum CBD offers a similar range as full-spectrum with minor cannabinoids, terpenes, essential oils, and flavonoids but is non-detect THC. It’s a great option for those who want to use CBD for allergies but want to avoid THC.
CBD isolate is the purest form of CBD. It’s refined to remove trace levels of THC and all other cannabis plant compounds. It’s best for individuals who may need CBD products without any other compounds.
Topical Solutions for Skin Allergies
Those who suffer from skin allergies could find that CBD topicals could improve various skin allergies.
A topical cream, balm, lotion, or salve infused with CBD that’s applied directly to the affected area could help support uncomfortable symptoms.
CBD’s potential to support inflammation may help with conditions like allergic contact dermatitis. It might also support inflammation associated with eczema or psoriasis. (12).
Topical cream or infused ointments are the most common way to support skin allergies. Applied directly to itchy rashes associated with allergic contact dermatitis and other skin allergies, CBD may provide potential localized improvment. (16)
Inhalation Methods for Seasonal Allergies
For seasonal allergies, utilizing inhalable CBD products could be effective in alleviating allergy symptoms.
Using a CBD vape pen can provide quick absorption, whether using it to help improve allergy symptoms or something else. This is because CBD is quickly absorbed into the bloodstream when inhaled via vapor or smoke. (13)
Sublingual CBD to Support Allergy Symptoms
Sublingual CBD oil is another product commonly used to address allergies.
While CBD taken sublingually doesn’t absorb into the bloodstream as quickly as inhalation, it does work quickly and may improve symptoms like sneezing and nasal congestion.
Taking CBD sublingually involves using the dropper to place CBD oil under the tongue. It should be held for 90 seconds before swallowing. This ensures it’s absorbed by the mucous membranes under the tongue and absorbs effectively into the body. (13)
The Optimal Dosage of CBD for Allergies
The optimal CBD dosage for allergies is different for everyone. Different people have different allergy symptoms, some more intense than others. If you’re interested in using CBD for allergies, determining your ideal dose is key.
Some individuals may consider starting with a dose range of 20-40mg of CBD per day. That said, everyone reacts differently to CBD based on various factors. (14)
Allergy type and symptoms play a large role in determining your ideal dose. So do personal factors like metabolism, weight, ECS health, and more.
This means you’ll want to experiment with your dose until you find your personal sweet spot. Consider starting with 20-40mg daily, increasing your intake by 5-10mg per week until you feel the effects you desire.
It’s always recommended to talk to a healthcare provider before taking CBD, especially if you have a severe allergic reaction or plan on consuming CBD with other medications.
The Potential of CBD as a Natural Antihistamine
Histamines are chemicals released by the immune system that play a large role in causing allergy symptoms. CBD has drawn interest within the medical community for its potential role as a natural antihistamine. (7)
Why is CBD suggested to be a promising natural alternative to common antihistamine drugs?
For one, CBD is shown to suppress mast cell signaling, which is responsible for releasing histamine and other chemicals involved in causing an allergic reaction. It may also decrease nasal congestion by influencing pathways that produce cells known to activate histamines. (7)
CBD also might control the activity of white blood cells that respond to allergens. This is associated with its immunosuppressive and anti-inflammatory potential.
The terpene A-pinene, which is found abundantly in hemp, contains anti-allergy potential, which may complement CBD’s antihistamine effects. This is a perfect example of the entourage effect in action. (11, 17)
Can You Be Allergic to CBD?
Preliminary evidence suggests that CBD may have potential for addressing allergy-related concerns, but is it possible to be allergic to CBD?
While rare, it is possible to have a CBD allergy. An allergy to CBD could show up in someone with a hemp allergy, terpene allergy, or general sensitivity to the cannabis sativa plant.
Individuals allergic to mold, pet dander, and pollen allergies may be more susceptible to a CBD allergy than others.
What does a CBD allergy look like? Symptoms of CBD or hemp allergies can manifest as skin irritations, headaches, respiratory issues, and difficulty breathing.
If you think you might be allergic to CBD, stop using it immediately and get in touch with a healthcare provider. You might consider specialized allergy testing like skin prick and blood tests for IgE antibodies. (15)
Environmental Factors That Can Make Allergies Worse
Some environmental factors can trigger allergy symptoms more than others. Weather changes, seasonal changes, pollution, and more can all greatly affect allergies. (4)
Knowing the source of your allergies can help you determine if CBD could be a natural solution to managing allergy symptoms.
If your allergies are seasonal, you can make small lifestyle changes that can help from developing severe allergic reactions. Avoiding outdoor activities during peak pollen times and using air purifiers indoors could enhance the potential benefits of CBD for allergy support.
All that said, it’s important to keep in mind that smoking CBD (or exposure to cannabis or cigarette smoke) could increase the risk of developing allergies and conditions like asthma.
Summary
The potential therapeutic benefits of CBD for allergies are gaining increased attention from allergy sufferers interested in an alternative to traditional allergy medications.
With its suggested anti-inflammatory, immunosuppressive, and antihistamine properties, CBD shows promise as an integrative health solution for allergies.
While more research is needed, preclinical studies and anecdotal reports suggest using CBD for allergies shows some real promise.
By determining the best product and dose for your personal needs, CBD might just provide a natural way to soothe your allergy symptoms and improve your quality of life.
Frequently Asked Questions
Can CBD really help with allergies?
Some research suggests that CBD may influence immune function and inflammation, which could have implications for allergies. We recommend contacting your doctor to see if CBD may be an option for you.
Is CBD a natural antihistamine?
There is research suggesting that CBD might influence histamine production and release, potentially acting as a natural antihistamine..
Is CBD oil good for hay fever?
Some individuals might consider CBD oil as a potential option for addressing hay fever, given its suggested influence on histamine.
Does CBD help with pet allergies?
Some pet owners may consider CBD as a potential means to support their pet’s immune system and inflammatory response.
1. Kucuksezer, U. C., Ozdemir, C., Akdis, M., & Akdis, C. A. (2013). Mechanisms of immune tolerance to allergens in children. Korean journal of pediatrics, 56(12), 505. https://doi.org/10.3345/kjp.2013.56.12.505
2. Vuolo, F., Petronilho, F., Sonai, B., Ritter, C., Hallak, J. E., Zuardi, A. W., … & Dal-Pizzol, F. (2015). Evaluation of serum cytokines levels and the role of cannabidiol treatment in animal model of asthma. Mediators of inflammation, 2015. https://doi.org/10.1155/2015/538670
3. Yang, X., Lee, D., Kim, H. W., Park, B., Lim, C., & Bae, E. J. (2023). Cannabidiol inhibits IGE‐Mediated mast cell degranulation and anaphylaxis in mice. Molecular Nutrition & Food Research. https://doi.org/10.1002/mnfr.202300136
4. Bozkurt, T. E. (2019). Endocannabinoid system in the airways. Molecules, 24(24), 4626. https://doi.org/10.3390/molecules24244626
5. Chiurchiù, V., Battistini, L., & Maccarrone, M. (2015). Endocannabinoid signaling in innate and adaptive immunity. Immunology, 144(3), 352-364. https://doi.org/10.1111/imm.12441
6. Atalay, S., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2019). Antioxidative and Anti-Inflammatory properties of cannabidiol. Antioxidants, 9(1), 21. https://doi.org/10.3390/antiox9010021
7. Vuolo, F., Abreu, S. C., Michels, M., Xisto, D. G., Blánco, N., Hallak, J. E. C., Zuardi, A. W., Crippa, J. a. S., Reis, C. M. D., Bahl, M. M., Pizzichinni, E., Da Silva, R. M., Pizzichinni, M., Rocco, P. R. M., & Dal‐Pizzol, F. (2019). Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma. European Journal of Pharmacology, 843, 251–259. https://doi.org/10.1016/j.ejphar.2018.11.029
8. Sugawara, K., Zákány, N., Hundt, T., Emelianov, V., Tsuruta, D., Schäfer, C., … & Paus, R. (2013). Cannabinoid receptor 1 controls human mucosal-type mast cell degranulation and maturation in situ. Journal of allergy and clinical immunology, 132(1), 182-193. https://doi.org/10.1016/j.jaci.2013.01.002
9. Peyravian, N., Deo, S., Daunert, S., & Jimenez, J. J. (2020). Cannabidiol as a novel therapeutic for immune modulation. ImmunoTargets and therapy, 131-140. https://doi.org/10.2147/ITT.S263690
10. Pauli, C. S., Conroy, M., Vanden Heuvel, B. D., & Park, S. H. (2020). Cannabidiol drugs clinical trial outcomes and adverse effects. Frontiers in pharmacology, 11, 63. https://doi.org/10.3389/fphar.2020.00063
11. Henshaw, F. R., Dewsbury, L. S., Lim, C. K., & Steiner, G. Z. (2021). The effects of cannabinoids on pro-and anti-inflammatory cytokines: a systematic review of in vivo studies. Cannabis and Cannabinoid Research, 6(3), 177-195. https://doi.org/10.1089/can.2020.0105
12. Baswan, S. M., Klosner, A. E., Glynn, K., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic potential of cannabidiol (CBD) for skin health and disorders. Clinical, cosmetic and investigational dermatology, 927-942. https://doi.org/10.2147/CCID.S286411
13. Millar, S. A., Stone, N. L., Yates, A. S., & O’Sullivan, S. E. (2018). A systematic review on the pharmacokinetics of cannabidiol in humans. Frontiers in pharmacology, 9, 1365. https://doi.org/10.3389/fphar.2018.01365
14. Larsen, C., & Shahinas, J. (2020). Dosage, efficacy, and safety of cannabidiol administration in adults: a systematic review of human trials. Journal of Clinical Medicine Research, 12(3), 129. https://doi.org/10.14740/jocmr4090
15. Alkhammash, S., Tsui, H., & Thomson, D. M. (2019). Cannabis and hemp seed allergy. The Journal of Allergy and Clinical Immunology: In Practice, 7(7), 2429-2430. https://doi.org/10.1016/j.jaip.2019.02.045
16. Baswan, S. M., Klosner, A. E., Glynn, K. M., Rajgopal, A., Malik, K., Yim, S., & Stern, N. (2020). Therapeutic Potential of Cannabidiol (CBD) for Skin Health and Disorders</p> Clinical, Cosmetic and Investigational Dermatology, Volume 13, 927–942. https://doi.org/10.2147/ccid.s286411